Administer by slow IV injection not to exceed 5 mg/min

Total dose not to exceed 50 mg

Monitor for anaphylaxis

Protamine only reverses ~60% of LMWH activity

1 mg Protamine Sulfate for every 1 mg of enoxaparin received

Additional 0.5 mg Protamine per 1 mg enoxaparin can be given after 30 minutes if clinical condition warrants

0.5 mg Protamine Sulfate for every 1 mg of enoxaparin received

Additional 0.25 mg Protamine per 1 mg enoxaparin can be given after 30 minutes if clinical condition warrants